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Drosophila position‐specific antigens resemble the vertebrate fibronectin‐receptor family.
Author(s) -
Leptin M.,
Aebersold R.,
Wilcox M.
Publication year - 1987
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1987.tb04856.x
Subject(s) - biology , antigen , vitronectin , leptin , glycoprotein , leptin receptor , receptor , microbiology and biotechnology , genetics , integrin , endocrinology , obesity
The Drosophila position‐specific (PS) antigens are a family of cell surface glycoprotein complexes thought to be involved in morphogenesis. Their overall structures and biochemical properties are similar to those of a group of vertebrate receptors, including those for fibronectin, fibrinogen and vitronectin, and also the leukocyte antigens Mac‐1, LFA‐1 and p150,95 and the VLA family of cell surface antigens. The N‐terminal sequences of the alpha subunits of some of these molecules are homologous to the N‐terminus of a PS antigen component. The Drosophila PS antigens thus appear to be homologous to these vertebrate receptors.