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Relationship between enhanced reactivation and mutagenesis of u.v.‐irradiated human cytomegalovirus in normal human cells.
Author(s) -
Dion M.,
Hamelin C.
Publication year - 1987
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1987.tb04768.x
Subject(s) - biology , human cytomegalovirus , mutagenesis , virology , microbiology and biotechnology , cytomegalovirus , mutation , herpesviridae , genetics , virus , gene , viral disease
The survival of u.v.‐irradiated human cytomegalovirus (HCMV) on u.v.‐irradiated human IAFP‐1 cells was increased over that on unirradiated cells. Irradiated virus had a higher forward mutation frequency towards temperature sensitivity in irradiated than in unirradiated cells. Enhanced reactivation of u.v.‐irradiated HCMV is thus mutagenic in normal human cells. This observation supports the possible induction of an error‐prone mode of DNA repair in u.v.‐irradiated mammalian cells.