Premium
Effect of the recombinant vaccinia viruses that express HTLV‐I envelope gene on HTLV‐I infection.
Author(s) -
Shida H.,
Tochikura T.,
Sato T.,
Konno T.,
Hirayoshi K.,
Seki M.,
Ito Y.,
Hatanaka M.,
Hinuma Y.,
Sugimoto M.
Publication year - 1987
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1987.tb02660.x
Subject(s) - virus , virology , vaccinia , biology , library science , recombinant dna , gene , genetics , computer science
The human T‐lymphotropic virus type I (HTLV‐I) is etiologically linked to adult T‐cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV‐I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV‐I in rabbits and had a protective effect against HTLV‐I infection.