Premium
Human CSF‐1: gene structure and alternative splicing of mRNA precursors.
Author(s) -
Ladner M. B.,
Martin G. A.,
Noble J. A.,
Nikoloff D. M.,
Tal R.,
Kawasaki E. S.,
White T. J.
Publication year - 1987
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1987.tb02561.x
Subject(s) - corporation , biology , alternative splicing , library science , gene , political science , genetics , computer science , messenger rna , law
Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor‐1 (CSF‐1). Characterization of the human CSF‐1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF‐1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3′ noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF‐1. Implications of differential splicing for the production and function of CSF‐1 are discussed.