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Human T‐cell tumours containing chromosome 14 inversion or translocation with breakpoints proximal to immunoglobulin joining regions at 14q32.
Author(s) -
MengleGaw L.,
Willard H. F.,
Smith C. I.,
Hammarström L.,
Fischer P.,
Sherrington P.,
Lucas G.,
Thompson P. W.,
Baer R.,
Rabbitts T. H.
Publication year - 1987
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1987.tb02501.x
Subject(s) - biology , breakpoint , chromosomal translocation , chromosomal inversion , chromosome , genetics , antibody , microbiology and biotechnology , karyotype , gene
T‐cell tumours are frequently found to carry an inversion of chromosome 14 (inv(14)) (q11;q32) or more rarely a chromosome 14 translocation t(14;14) with the same cytogenetic breakpoints (q11;q32). We have examined the molecular junctions of an inv(14) and a translocation t(14;14) using T‐cell receptor (TCR) alpha joining (J) region probes. Both of these chromosomal abnormalities have breakpoints within the TCR J alpha locus at 14q11 and both have breakpoints which are proximal (i.e. on the centromeric side) to the immunoglobulin heavy chain JH region at 14q32. The cloned segments corresponding to the junctions at 14q32 are not associated with obvious immunoglobulin‐like sequences. This contrasts to the previously described inv(14) in the cell line SUP‐T1 and places a potential cluster of chromosome 14 breakpoints downstream of the Ig JH locus. The possible role of the varying breakpoints in the development of these tumours is discussed.