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Involvement of ras in sexual differentiation but not in growth control in fission yeast
Author(s) -
NadinDavis S.A.,
Nasim A.,
Beach D.
Publication year - 1986
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1986.tb04593.x
Subject(s) - research council , library science , spring (device) , section (typography) , biology , engineering , government (linguistics) , mechanical engineering , linguistics , philosophy , computer science , advertising , business
The function of the ras + gene of Schizosaccharomyces pombe has been studied by constructing null and activated alleles of this gene. An activated allele ( ras Val 12 ) inhibits conjugation but has no effect on cell growth, entry into stationary phase or sporulation. The phenotype of ras Val 12 is distinct from that caused by elevating the intracellular level of cAMP. This supports the hypothesis that ras of fission yeast does not modulate adenylate cyclase in a manner analogous to S. cerevisiae RAS . Introduction of a human ras sequence into fission yeast cells containing a non‐functional null allele of ras restored the sexual differentiation process thus indicating that the human sequence can complement S. pombe ras . Our data suggest that although ras genes are highly conserved across a considerable evolutionary divide, the cellular function of the ras gene product varies in different organisms.