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The 3′ region of bovine leukemia virus genome encodes a trans‐activator protein.
Author(s) -
Rosen C.A.,
Sodroski J.G.,
Willems L.,
Kettmann R.,
Campbell K.,
Zaya R.,
Burny A.,
Haseltine W.A.
Publication year - 1986
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1986.tb04538.x
Subject(s) - biology , library science , activator (genetics) , information retrieval , gene , genetics , computer science
The genome of bovine leukemia virus (BLV) contains several overlapping, long open reading frames 3′ to the envelope gene. Experiments presented here show that the cDNA encompassing the X region open reading frames encodes a trans‐activator function capable of increasing the level of gene expression directed by the BLV long terminal repeat sequences. This study provides further evidence of the structural and functional similarities of the bovine leukemia virus and the human T lymphotropic viruses, HTLV‐I and HTLV‐II.