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The mouse E beta 2 gene: a class II MHC beta gene with limited intraspecies polymorphism and an unusual pattern of transcription.
Author(s) -
Braunstein N.S.,
Germain R.N.
Publication year - 1986
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1986.tb04523.x
Subject(s) - biology , gene , major histocompatibility complex , genetics , microbiology and biotechnology , transcription (linguistics) , beta (programming language) , mhc class i , gene product , gene expression , philosophy , linguistics , computer science , programming language
Analysis of genomic clones containing the E beta 2 region from the mouse major histocompatibility complex (MHC) reveals a gene that is similar to conventional class II beta genes in its overall organization and sequence but unusual in that it shows limited intraspecies allelic polymorphism. Like the conventional class II beta genes, the E beta 2 gene is transcriptionally active in a variety of B lymphoid cells. However, its transcripts consist of multiple polyadenylated species from 1.8 to 3.6 kb in size which are present at only approximately 1/20 the level of E beta 1 mRNA in the same cells. In addition, unlike other class II genes, E beta 2 transcription is not induced by gamma‐interferon treatment of macrophage/monocyte tumor lines. These distinctive features suggest that the E beta 2 gene product may have a unique functional role, different from that of previously studied class II proteins.