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Coordination of murine parotid secretory protein and salivary amylase expression.
Author(s) -
Poulsen K.,
Jakobsen B.K.,
Mikkelsen B.M.,
Harmark K.,
Nielsen J.T.,
Hjorth J.P.
Publication year - 1986
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1986.tb04441.x
Subject(s) - biology , amylase , salivary proteins , saliva , salivary gland , parotid gland , microbiology and biotechnology , genetics , enzyme , biochemistry , pathology , medicine
PSP, parotid secretory protein, and salivary amylase are the major secretory proteins of mouse parotid gland where they appear in a constant ratio. Here we describe the isolation of the PSP gene and show through expression analysis on this and the salivary amylase gene that the two genes are transcribed in a coordinate fashion in adult animals, whereas the activation profiles are different during postnatal development. An explanation is put forward that involves activation of the genes at different stages of the acinar cell differentiation, leading in adults to the maximal and thus proportionate expression.