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Retroviral characteristics of the long terminal repeat of murine E.Tn sequences.
Author(s) -
Kaghad M.,
Maillet L.,
Brûlet P.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb04022.x
Subject(s) - biology , long terminal repeat , terminal (telecommunication) , genetics , base sequence , virology , microbiology and biotechnology , gene , genome , telecommunications , computer science
E.Tn sequences form a family of long moderately repeated sequences which are abundantly transcribed in the pluripotent cell lineage between day 3.5 and 7.5 of early mouse embryogenesis. The structure of the long terminal repeat (LTR) bordering the E.Tn sequences has been investigated by nucleotide sequencing, primer extension and S1 mapping experiments. This has allowed the identification of U3, R and U5 domains, and of several other structural features all of which are characteristics of retroviral LTRs.