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Human proto‐oncogene c‐mos maps to 8q11.
Author(s) -
Caubet J.F.,
MathieuMahul D.,
Bernheim A.,
Larsen C.J.,
Berger R.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03921.x
Subject(s) - biology , genetics , computational biology
The c‐mos proto‐oncogene is the cellular counterpart of the viral oncogene v‐mos isolated from Moloney murine sarcoma virus. The c‐mos gene locus has previously been assigned to human chromosome 8. By both in situ hybridization and molecular hydridization to sorted chromosome DNA (using a c‐mos probe) we have localized the c‐mos gene to band 8q11. This regional localization is at variance with the one previously reported at 8q22 and may explain why no rearrangement of c‐mos has been found in acute leukaemia with the chromosomal translocation t(8;21)(q22;q22).