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Structure of the murine Thy‐1 gene.
Author(s) -
Giguére V.,
Isobe K.,
Grosveld F.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03886.x
Subject(s) - polyadenylation , biology , gene , exon , tata box , intron , genetics , microbiology and biotechnology , untranslated region , sequence (biology) , promoter , messenger rna , gene expression
We have cloned the murine Thy‐1.1 (AKR) and Thy‐1.2 (Balb/c) genes. The complete exon/intron structure and the nucleotide sequence of the Thy‐1.2 gene was determined. The gene contains four exons and three intervening sequences. The complete transcriptional unit gives rise to a tissue and developmental stage‐specific mRNA of 1850 bp. The 5′ end of the gene has multiple initiation sites and a non‐TATA box promoter. The 3′ end shows a single polyadenylation site after a very long untranslated region.