Premium
Proviral activation of the putative oncogene Pim‐1 in MuLV induced T‐cell lymphomas.
Author(s) -
Selten G.,
Cuypers H.T.,
Berns A.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03852.x
Subject(s) - biology , oncogene , virology , genetics , cancer research , lymphoma , oncogene proteins , cell , gene , immunology , regulation of gene expression , cell cycle
Proviral integration near the Pim‐1 gene is frequently observed in murine leukemia virus induced T‐cell lymphomas in mice. Integration in the Pim‐1 domain is associated with the presence of enhanced levels of a Pim‐1 mRNA, which is normally expressed as a predominant 2.8 kb species at low levels in lymphoid tissues. The majority of integrations occurred in the 3′ region of the Pim‐1 transcription unit. This resulted in transcripts ranging in size from 2.0 to 2.6 kb, which were terminated in the 5′ proviral LTR. Dependent on the site of integration up to 1300 bases of Pim‐1 specific sequences were missing from the modified Pim‐1 mRNA in these lymphomas.