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The chromosomal location of T‐cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia.
Author(s) -
Rabbitts T.H.,
Lefranc M.P.,
Stinson M.A.,
Sims J.E.,
Schroder J.,
Steinmetz M.,
Spurr N.L.,
Solomon E.,
Goodfellow P.N.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03803.x
Subject(s) - biology , gene , genetics
We have examined the chromosomal location of human T cell‐specific genes which are involved in antigen recognition and of a gene which specifically rearranges in T cells. The genes encoding both the variable and constant region segments of the T cell receptor alpha chain are found on chromosome 14 while the delta chain gene of the T cell receptor‐associated T3 complex is localised to chromosome 11. Further, the two tandemly arranged T cell‐specific rearranging genes, designated gamma, were mapped to chromosome 7, but apparently not closely linked to the previously mapped T cell receptor beta‐chain gene. The locations of the three different genes, which undergo rearrangement in T cells, may correlate with the chromosomal breakpoints known to be involved in translocations within abnormal human T cells.