Premium
Transcripts from an aberrantly re‐arranged human T‐cell receptor beta‐chain gene.
Author(s) -
Collins M.K.,
Kissonerghis A.M.,
Dunne M.J.,
Watson C.J.,
Rigby P.W.,
Owen M.J.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb03762.x
Subject(s) - watson , biology , gene , cdna library , combinatorics , complementary dna , genetics , computer science , artificial intelligence , mathematics
A number of cDNA clones homologous to the human T‐cell receptor beta‐chain gene have been isolated from a library constructed from the human leukaemic cell line Jurkat. The nucleotide sequences of two of these clones demonstrate that Jurkat synthesizes an RNA, probably derived from an aberrantly rearranged C beta 1 gene, which cannot encode a functional beta‐chain. This transcript contains a novel joining region and similar transcripts appear to be relatively abundant in several T‐cell lines.