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Structure and expression of the human haptoglobin locus.
Author(s) -
Bensi G.,
Raugei G.,
Klefenz H.,
Cortese R.
Publication year - 1985
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1985.tb02325.x
Subject(s) - biology , haptoglobin , locus (genetics) , genetics , expression (computer science) , computational biology , microbiology and biotechnology , gene , immunology , computer science , programming language
Human genomic clones of the haptoglobin Hp1F and the ‘haptoglobin related’ gene (Hpr) have been isolated. The two genes are adjacent, spanning a region of approximately 21 kb. A comparison of their coding sequences shows that Hpr differs from Hp1F at 28 codons. Northern blot and primer elongation analyses with human liver RNA show that the haptoglobin gene Hp1F appears to be transcribed some 1000‐fold less in fetal than in adult liver. In adult liver the amount of Hpr mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000‐fold that of the Hp1F gene. No Hpr mRNA can be detected in fetal liver.