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Comparison of the entire genomes of bovine leukemia virus and human T‐cell leukemia virus and characterization of their unidentified open reading frames.
Author(s) -
Sagata N.,
Yasunaga T.,
Ohishi K.,
TsuzukuKawamura J.,
Onuma M.,
Ikawa Y.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb02283.x
Subject(s) - biology , genome , open reading frame , bovine leukemia virus , leukemia , virus , reading (process) , virology , gene , library science , computational biology , genetics , computer science , linguistics , peptide sequence , philosophy
We have compared the sequence of the entire genomes of bovine leukemia virus (BLV) and human T‐cell leukemia virus type I (HTLV‐I). Both the gag and pol genes show overall strong homologies indicating the close evolutionary relationship of the two retroviruses. However, a surface glycoprotein portion of the env gene shows no appreciable homology, which probably reflects a difference in their host ranges. The 3′ end portion of the BLV genome (designated as pXBL) contains an unidentified long open reading frame that has a typical protein‐coding property. The potential product of this open reading frame may be a glycoprotein of approximately 40 000 daltons. We note that its amino acid sequence shows low but appreciable homology, especially in its N‐terminal quarter, to that of the HTLV‐I counterpart (pX product), and we thus suggest that BLV pXBL and HTLV‐I pX have diverged from a common ancestral gene. It is tentatively concluded that both the putative pXBL and pX products are respectively produced from a spliced mRNA.