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Tracts of high or low sequence divergence in the mouse major histocompatibility complex.
Author(s) -
Steinmetz M.,
Malissen M.,
Hood L.,
Orn A.,
Maki R.A.,
Dastoornikoo G.R.,
Stephan D.,
Gibb E.,
Romaniuk R.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb02246.x
Subject(s) - biology , major histocompatibility complex , sequence (biology) , divergence (linguistics) , genetics , histocompatibility , evolutionary biology , computational biology , gene , antigen , human leukocyte antigen , linguistics , philosophy
The K, I and S regions of the mouse major histocompatibility complex (MHC) are composed of long tracts of DNA which differ in sequence divergence. A correlation exists between the location of an MHC gene in a variable or conserved chromosomal tract and the degree of polymorphism and diversity of the proteins encoded by its alleles. Variable tracts appear to be the result of mechanisms which mutate certain coding and non‐coding sequences to the same extent and selective pressures operating on the genes.