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The gene for the hypothalamic peptide hormone oxytocin is highly expressed in the bovine corpus luteum: biosynthesis, structure and sequence analysis.
Author(s) -
Ivell R.,
Richter D.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb02139.x
Subject(s) - corpus luteum , oxytocin , luteal phase , biology , neurophysins , hypothalamus , complementary dna , gene , gene expression , endocrinology , messenger rna , medicine , microbiology and biotechnology , genetics , hormone
Expression of the vasopressin and oxytocin genes has been described so far only in the hypothalamus. We report here that at least the oxytocin gene is highly transcribed in the bovine corpus luteum during the mid‐luteal phase of the oestrous cycle. Luteal cDNA sequence analysis as well as cell‐free translation studies showed that the luteal mRNA is essentially similar to that in the hypothalamus, except that in the corpus luteum the poly(A) tail of this mRNA is shorter. When calculating the relative amounts per organ, the active corpus luteum produces approximately 250 times more oxytocin mRNA than a single hypothalamus.