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Two non‐allelic human interferon alpha genes with identical coding regions.
Author(s) -
Todokoro K.,
Kioussis D.,
Weissmann C.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb02050.x
Subject(s) - gene , biology , genetics , coding region , alpha interferon , allele , interferon
A hitherto undescribed human interferon‐alpha (IFN‐alpha) gene, IFN‐alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN‐alpha 1; the 5′ and 3′ non‐coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus‐induced leukocytes.