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Altered globin gene transcription pattern and the presence of a 7‐8 kb alpha A globin gene transcript in avian erythroblastosis virus‐transformed cells.
Author(s) -
Therwath A.,
Mengod G.,
Scherrer K.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb01835.x
Subject(s) - biology , gene , microbiology and biotechnology , transcription (linguistics) , globin , gene expression , genetics , philosophy , linguistics
Immature chick erythroid cells transformed by avian erythroblastosis virus (AEV) display an altered pattern of globin gene transcription leading to the abortive phenotypic expression of such transcripts. Detectable adult globin gene‐specific RNA sequences, confined exclusively to the nucleus, are uniquely of the alpha A type. The alpha A globin‐specific sequences occur in transcripts 7‐8 kb long from which the 5′ contiguous alpha D gene product is absent, and also in fragments smaller than 9S globin mRNA. The implication of this observation for schemes of post‐transcriptional regulation of gene expression and viral transformation are discussed.