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Sorbitol dehydrogenase is a zinc enzyme.
Author(s) -
Jeffery J.,
Chesters J.,
Mills C.,
Sadler P.J.,
Jörnvall H.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb01811.x
Subject(s) - biology , sorbitol dehydrogenase , enzyme , sorbitol , biochemistry , zinc , dehydrogenase , materials science , metallurgy
Evidence is given that tetrameric sorbitol dehydrogenase from sheep liver contains one zinc atom per subunit, most probably located at the active site, and no other specifically bound zinc or iron atom. In alcohol dehydrogenases that are structurally related to sorbitol dehydrogenase, more than one zinc atom per subunit can complicate investigations of zinc atom function. Therefore, sorbitol dehydrogenase will be particularly valuable for defining the precise roles of zinc in alcohol and polyol dehydrogenases, and for establishing correlations of structure and function with other important zinc‐containing proteins.