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Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.
Author(s) -
Morley B.J.,
Campbell R.D.
Publication year - 1984
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1984.tb01776.x
Subject(s) - biology , complementary dna , microbiology and biotechnology , genetics , gene , homology (biology) , coding region , complement factor b , genomic dna , complement (music) , antibody , complement system , complementation , phenotype
The amino acid sequence of Ba, a fragment of the complement protein Factor B, has been determined from the sequence of its corresponding cDNA. Ba is composed of 234 amino acids and from the sequence two striking regions of internal homology are apparent which are related to a third less homologous region. Analysis of cloned genomic DNA using an 81‐bp cDNA probe containing coding information for part of a leader peptide and nine amino acids at the N terminus of Ba has established the extent of the 5′ end of the Factor B gene and shown that the region of the gene encoding Ba is approximately 1.6 kb in length.