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Structure of two human beta‐actin‐related processed genes one of which is located next to a simple repetitive sequence.
Author(s) -
Moos M.,
Gallwitz D.
Publication year - 1983
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1983.tb01496.x
Subject(s) - pseudogene , biology , gene , genetics , sequence (biology) , beta (programming language) , human genome , repeated sequence , genome , computational biology , computer science , programming language
From a human gene library we have isolated and sequenced a beta‐actin‐like pseudogene, H beta Ac‐psi 2, which lacks intervening sequences and contains several mutations resulting in frame‐shifts, stop codons and in a departure from the known beta‐actin protein sequence. We have also extended our sequence work on the intronless human beta‐actin‐related pseudogene H beta Ac‐psi 1 described previously and we find that both genes are processed genes ending in a poly(dA) tract and flanked by direct repeats. The gene H beta Ac‐psi 2 is preceded by a 230‐bp region in which the simple sequence 5′‐GAAA‐3′ is repeated greater than 40 times. This satellite‐like sequence is highly repetitive in the human genome.