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Expression of c‐onc genes: c‐fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.
Author(s) -
Müller R.,
Verma I.M.,
Adamson E.D.
Publication year - 1983
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1983.tb01484.x
Subject(s) - biology , cytotrophoblast , placenta , amnion , syncytiotrophoblast , fetal membrane , yolk sac , decidua , conceptus , andrology , fetus , gene expression , microbiology and biotechnology , embryo , endocrinology , gene , medicine , genetics , pregnancy
The c‐onc genes c‐fos and c‐fms are expressed at high levels specifically in mouse extra‐embryonal tissues. Here, we report the results of a detailed analysis of expression of these genes within the developing placenta and extra‐embryonal membranes (i.e., yolk sac and amnion). (i) The c‐fos gene is expressed at relatively high, but nearly constant levels in the undissected placenta throughout gestation. (ii) The level of c‐fos transcripts is greater than or equal to 15‐fold higher in the separated outer portion of the midgestation placenta (primarily undifferentiated fetus‐derived cytotrophoblast maternal decidua) relative to the inner moiety (predominantly differentiated syncytiotrophoblast). (iii) In the inner placenta and in the extra‐embryonal membranes c‐fos transcripts accumulate as gestation proceeds. The abundance of c‐fos transcripts in the micro‐surgically isolated 18th day amnion reaches a level which is two orders of magnitude greater than that in midgestation fetuses, and is thus close to the level of v‐fos transcripts in virus‐transformed cells. (iv) The distribution of c‐fos transcripts within the developing extra‐embryonal tissues is markedly different from that of the c‐fms gene. It is suggested that the c‐fos and c‐fms proteins may participate in differentiation, growth or transport processes occurring in mouse extra‐embryonal tissues.