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Virus‐specific phosphoproteins in simian sarcoma virus‐transformed primate cells.
Author(s) -
Born M.,
Helm K.,
Deinhardt F.
Publication year - 1982
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1982.tb01291.x
Subject(s) - biology , virus , simian , virology , antiserum , in vitro , primate , microbiology and biotechnology , antibody , genetics , neuroscience
Cells transformed by simian sarcoma virus (SSV) express a 115000‐dalton protein (p115) that is precipitated by a goat antiserum to disrupted SSV/SSAV‐infected and transformed cells but not by antibodies directed against the viral gag protein, p30, or envelope proteins. The protein is detected in productively as well as in nonproductively infected, transformed cells. It is not present in untransformed cells infected with helper virus (SSAV). The protein can be phosphorylated in vivo and in vitro at the tyrosine residue and SSV‐transformed cells contain elevated levels of phosphotyrosine.