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Homologies between different procaryotic DNA‐binding regulatory proteins and between their sites of action.
Author(s) -
GicquelSanzey B.,
Cossart P.
Publication year - 1982
Publication title -
the embo journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.484
H-Index - 392
eISSN - 1460-2075
pISSN - 0261-4189
DOI - 10.1002/j.1460-2075.1982.tb01213.x
Subject(s) - biology , dna binding protein , dna , plasma protein binding , escherichia coli proteins , genetics , binding site , dna binding site , action (physics) , bacterial protein , computational biology , microbiology and biotechnology , gene , transcription factor , gene expression , promoter , physics , quantum mechanics
Comparison of the amino acid sequences of 13 procaryotic regulatory proteins, including the products of genes crp (catabolite activator protein; CAP), lacI, galR, lexA, lysR, araC, trpR, and tnpR of Escherichia coli, of genes cI, cII and cro of phage lambda, cro of phage 434, and c2 of phage P22, has revealed two regions of homology. The sites of action of these proteins also share common features in their DNA sequence. Taking into account the models proposed for the lambda repressors, cro and cI, and for CAP, a general type of DNA‐protein interaction is suggested.