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Chemoprophylaxis of dental patients with prosthetic joints: a simulation model
Author(s) -
Jacobson JJ,
Schweitzer S,
DePorter DJ,
Lee JJ
Publication year - 1988
Publication title -
journal of dental education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 68
eISSN - 1930-7837
pISSN - 0022-0337
DOI - 10.1002/j.0022-0337.1988.52.11.tb02251.x
Subject(s) - chemoprophylaxis , medicine , antibiotic prophylaxis , penicillin , antibiotics , prophylactic antibiotic , dentistry , infection risk , intensive care medicine , surgery , microbiology and biotechnology , biology
A computer simulation model was created to assess the risks and effects of no prophylaxis, oral penicillin, and oral cephalexin regimens for dental patients at risk for late prosthetic joint infection (LPJI). Given the assumptions made, this analysis suggests that there is a very small risk of LPJI (29–68 cases per 10(6) dental visits), which is outweighed by a greater risk of death from a fatal antibiotic reaction. Thus, routine predental antibiotic prophylaxis for all dental patients with prosthetic joints may lead to higher mortality. However, clinical experience suggests that antibiotic prophylaxis may be appropriate in “high risk” patients.