Heparin—A unique stimulator of human colon cancer cells' growth | Zendy

Chatzinikolaou Georgia | Zendy; Nikitovic Dragana | Zendy; Asimakopoulou Athanasia | Zendy; Tsatsakis Aristidis | Zendy; Karamanos Nikos K. | Zendy; Tzanakakis George N. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Heparin—A unique stimulator of human colon cancer cells' growth

Author(s) -

Chatzinikolaou Georgia,

Nikitovic Dragana,

Asimakopoulou Athanasia,

Tsatsakis Aristidis,

Karamanos Nikos K.,

Tzanakakis George N.

Publication year - 2008

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1002/iub.70

Subject(s) - sulfation , glycosaminoglycan , extracellular matrix , heparin , heparan sulfate , cell culture , metastasis , cell growth , fibroblast growth factor , colorectal cancer , cancer cell , microbiology and biotechnology , cancer , cell , biology , chemistry , endogeny , biochemistry , cancer research , receptor , genetics

The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular functions. In the present study, the effects of GAGs on the proliferation of HT29, SW1116, and HCT116 human colon cancer cell lines were examined using exogenously added GAGs, an inhibitor of endogenous GAG sulfation and specific glycosidase digestions. Our results demonstrate that colon cancer cell growth was exclusively stimulated by exogenously added heparin and insensitive to endogenous GAGs/PGs production, in a sulfation pattern‐related manner. Treatment of the tested cell lines with the FGF‐2 neutralizing antibody showed that the stimulatory effect of heparin on the cells' growth was not FGF‐2‐dependent. Responsiveness of colon cancer cell lines to exogenous heparin/heparan sulfate may play a role in their growth and metastasis. © 2008 IUBMB IUBMB Life, 60(5): 333–340, 2008

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research