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Livin regulates prostate cancer cell invasion by impacting the NF‐κB signaling pathway and the expression of FN and CXCR4
Author(s) -
Chen Feng,
Yang Deyong,
Wang Shujing,
Che Xiangyu,
Wang Jianbo,
Li Xiancheng,
Zhang Zhiwei,
Chen Xiaochi,
Song Xishuang
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.606
Subject(s) - lncap , cancer research , prostate cancer , inhibitor of apoptosis , cell growth , signal transduction , apoptosis , metastasis , cell cycle , cxcr4 , biology , cancer , small interfering rna , cell , microbiology and biotechnology , programmed cell death , immunology , cell culture , transfection , inflammation , chemokine , biochemistry , genetics
Abstract Prostate cancer (PCa) has the second highest mortality rate of all tumor‐related diseases for males in Western countries, and the incidence of PCa in China is increasing. Previous studies have proven that inhibitor of apoptosis proteins (IAPs) can regulate tumor cell invasion and metastasis. Livin is the most recently identified IAP. Our previous study showed that Livin might play an important role in the initiation of human PCa and that Livin‐α might promote cell proliferation by regulating the G1–S cell cycle transition. However, whether Livin, as an IAP, can regulate the invasive ability of PCa cells remains unknown. In this study, we found that the expression of Livin was higher in metastatic PCa tissues than in nonmetastatic tissues and that the expression of Livin was downregulated/upregulated by small interfering RNA/vector, which could inhibit/promote PC‐3/LNCaP cell invasion. This action was related to the impact of Livin on nuclear factor‐κB (NF‐κB) and its downstream signaling pathway, including FN and CXCR4. Together, our findings suggested that Livin might regulate tumor cell invasion in PCa directly, and that Livin might be an ideal candidate for preventing tumor cell invasion. © 2012 IUBMB IUBMB Life, 2012