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Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals
Author(s) -
Wang Chunxia,
Guo Feifan
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.605
Subject(s) - atf4 , transcription factor , regulator , lipid metabolism , carbohydrate metabolism , biology , metabolism , homeostasis , microbiology and biotechnology , biochemistry , gene
It has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy homeostasis, insulin secretion, and sensitivity, suggesting that ATF4 is a master regulator of metabolism. This review summarizes the most recent progress in the understanding of the novel roles of ATF4 in the regulation of metabolism. © 2012 IUBMB IUBMB Life, 2012.