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Tyrosine phosphorylation and liver regeneration: A glance at intracellular transducers
Author(s) -
Pagano Mario Angelo,
Tibaldi Elena,
Gringeri Enrico,
Brunati Anna Maria
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.576
Subject(s) - protein tyrosine phosphatase , sh2 domain , phosphorylation , tyrosine phosphorylation , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , receptor tyrosine kinase , biology , tyrosine , liver regeneration , signal transduction , tyrosine kinase , extracellular , intracellular , protein phosphorylation , kinase , regeneration (biology) , biochemistry , protein kinase a
Liver regeneration (LR) is a compensatory growth that occurs in response to resection or injury of the liver aimed at restoring the liver mass and maintaining body homeostasis. The activation of intracellular signaling pathways due to extracellular stimuli mainly reflects a highly coordinated spatial and temporal organization of phosphotyrosine‐based signals generated by the concerted action of three basic functional modules, namely protein tyrosine kinases, protein tyrosine phosphatases, and the Src homology 2 (SH2) domain. In this review, we have selected a set of signaling proteins downstream of activated cytokine and growth factor receptors that highlight the multifaceted aspects of tyrosine phosphorylation with their impact on the course of LR. Besides being a process of remarkable biological interest, LR has recently emerged as a model for dissecting molecular mechanisms underlying diverse pathophysiological states, offering new perspectives in primarily, but not only, managing life‐threatening liver diseases. © 2011 IUBMB IUBMB Life, 2011