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On a heuristic point of view concerning the expression of numerous genes during the cell cycle
Author(s) -
Cooper Stephen
Publication year - 2012
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.571
Subject(s) - heuristic , expression (computer science) , gene , computational biology , point (geometry) , biology , cell cycle , microbiology and biotechnology , mathematics , computer science , genetics , mathematical optimization , geometry , programming language
The current model of the eukaryotic cell cycle proposes that numerous genes are expressed at different times during the cell cycle. The existence of myriad control points for gene expression leads to theoretical and logical problems for cell cycle control. Each expressed gene requires a control element to appear in a cell‐cycle specific manner; this control element requires another control element and so on, ad infinitum . There are also experimental problems with the current model based on ineffective synchronization methods and problems with microarray measurements of mRNA. Equally important, the efficacy of mRNA variation in affecting changes in protein content is negligible. An alternative view of the cell cycle proposes cycle‐independent, invariant accumulation of mRNA during the cell cycle with decreases of specific proteins occurring only during the mitotic period of the cell cycle. © 2011 IUBMB IUBMB Life, 2011.