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Insights into Acinetobacter baumannii pathogenicity
Author(s) -
Cerqueira Gustavo M.,
Peleg Anton Y.
Publication year - 2011
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.533
Subject(s) - acinetobacter baumannii , acinetobacter , organism , microbiology and biotechnology , virulence , biology , pathogenicity , outbreak , human pathogen , adaptability , antibiotics , virology , pseudomonas aeruginosa , gene , bacteria , genetics , ecology
Acinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter , particularly Acinetobacter baumannii , has become a “red‐alert” human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life‐threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism. © 2011 IUBMB IUBMB Life, 63(12): 1055–1060, 2011