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Many routes to a micro RNA
Author(s) -
Yeo Janet H. C.,
Chong Mark M. W.
Publication year - 2011
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.524
Subject(s) - biogenesis , microrna , biology , rna , function (biology) , computational biology , small rna , gene expression , rna processing , gene , microbiology and biotechnology , regulation of gene expression , rna binding protein , genetics
Micro RNAs (miRNAs) are ∼22 nt small RNAs that function as posttranscriptional negative regulators of gene expression. Thousands of these molecules have so far been identified across the metazoan and plant kingdoms. Although most miRNAs share the same biogenesis pathway, numerous noncanonical miRNAs and other small RNAs have also been identified. In this review, we will discuss these alternate small RNA biogenesis pathways as well as recent discoveries of non‐miRNA functions of the miRNA biogenesis machinery. This review will focus only on metazoan pathways. © 2011 IUBMB IUBMB Life, 63(11): 972–978, 2011