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Gene expression under laser and light‐emitting diodes radiation for modulation of cell adhesion: Possible applications for biotechnology
Author(s) -
Karu Tiina,
Pyatibrat Ludmila
Publication year - 2011
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.514
Subject(s) - adhesion , laser , optoelectronics , microbiology and biotechnology , diode , radiation , gene expression , cell adhesion , modulation (music) , nanotechnology , gene , materials science , chemistry , biology , optics , genetics , physics , acoustics , composite material
Experimental data about the modulation of adhesion and proliferation of anchorage‐dependent HeLa cells with monochromatic or quasimonochromatic radiation in red to near‐infrared region are presented. Cell adhesion and proliferation can be increased by irradiation with light of certain wavelengths (maxima in action spectrum are 619, 675, 740, 760, and 820 nm) or decreased when the activity of photoacceptor (cytochrome c oxidase in mitochondrial respiratory chain) is inhibited by chemicals before the irradiation. This modality allows controlling the number of attached and/or proliferating cells. Possible biotechnology applications of this method are outlined. © 2011 IUBMB IUBMB Life, 63(9): 747–753, 2011