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17β‐estradiol regulates estrogen receptor α monoubiquitination
Author(s) -
La Rosa Piergiorgio,
Marino and Maria,
Acconcia Filippo
Publication year - 2011
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.414
Subject(s) - biology , estrogen receptor , microbiology and biotechnology , estrogen , genetics , cancer , breast cancer
Monoubiquitination is a nonproteolytic signal involved in a network of several different physiological processes. Recently, monoubiquitination has been discovered as a new post‐transductional modification of the estrogen receptor α (ERα). However, at present no information is available about the role of the cognate ligand 17β‐estradiol (E2) in modulating this receptor post‐transductional modification. Thus, we studied the E2‐dependent modulation of ERα monoubiquitination in different cell lines. Here, we report that ERα monoubiquitination isnegatively modulated by E2. These results demonstrate thatERα monoubiquitination represents a new signalling modification that may modulate the E2:ERα‐regulated cellular processes. © 2011 IUBMB IUBMB Life,63(1):49–53, 2011