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MicroRNAs and other small silencing RNAs in cancer
Author(s) -
Rovira Carlos,
Güida Maria C.,
Cayota Alfonso
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.399
Subject(s) - microrna , gene silencing , cancer , biology , rna , function (biology) , computational biology , small nucleolar rna , rna silencing , long non coding rna , small rna , non coding rna , rna interference , bioinformatics , microbiology and biotechnology , genetics , gene
Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognosis, and treatment of cancer. We also describe the possible mechanisms underlying small RNA‐mediated transformation and outline the future describing new small RNA families with great potential in cancer biology. © 2010 IUBMB IUBMB Life, 62(12): 859–968