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Functional and structural aspects of helicobacter pylori acidic stress response factors
Author(s) -
Zanotti Giuseppe,
Cendron Laura
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.382
Subject(s) - helicobacter pylori , adaptation (eye) , context (archaeology) , bacteria , function (biology) , gene , biology , fight or flight response , niche , gene expression , microbiology and biotechnology , biochemistry , computational biology , genetics , neuroscience , paleontology
Helicobacter pylori is a striking example of adaptation of a bacterium to a very peculiar niche, the human stomach. Despite being a neutralophile, a sophisticated control of gene expression allows it to live and to proliferate in an environment that cycles from nearly neutral to very acidic. Despite the numerous studies performed on the mechanisms of acid adaptation, the physiological function of a large part of the genes products that are up‐regulated or down‐regulated is often not clear, in particular in the context of the response of the bacterium to an acidic stress. In this review, we discuss the molecular and functional aspects of some of the proteins that are commonly found overexpressed during the acid stress. © 2010 IUBMB IUBMB Life, 62(10): 715–723, 2010