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The multifaceted effects of granulocyte colony‐stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis
Author(s) -
Martins Andrew,
Han Jiahuai,
Kim Sung O.
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.361
Subject(s) - immune system , granulocyte macrophage colony stimulating factor , granulocyte , haematopoiesis , homeostasis , immunology , biology , granulocyte colony stimulating factor , colony stimulating factor , myeloid , cytokine , microbiology and biotechnology , stem cell , genetics , chemotherapy
The three colony‐stimulating factors, granulocyte/macrophage colony‐stimulating factor (GM‐CSF), macrophage colony‐stimulating factor (M‐CSF), and granulocyte colony‐stimulating factor (G‐CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM‐CSF and M‐CSF, G‐CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G‐CSF, endogenous G‐CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G‐CSF in immunomodulation and intestinal immune homeostasis. © 2010 IUBMB IUBMB Life, 62(8): 611–617, 2010.