Premium
cAMP/Ca 2+ response element‐binding protein plays a central role in the biogenesis of respiratory chain proteins in mammalian cells
Author(s) -
De Rasmo Domenico,
Signorile Anna,
Papa Francesco,
Roca Emilio,
Papa Sergio
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.342
Subject(s) - nrf1 , creb , mitochondrial biogenesis , microbiology and biotechnology , creb1 , biology , phosphorylation , transcription factor , tfam , signal transduction , transcriptional regulation , protein kinase a , cyclic amp response element binding protein , respiratory chain , mitochondrion , biochemistry , gene
In mammalian cells, promotion of mitochondrial biogenesis by various agents involves cAMP and Ca 2+ ‐mediated signal transduction pathways. Recruitment of these pathways results in phosphorylation by cAMP and Ca 2+ ‐dependent protein kinases of cAMP/Ca 2+ response element‐binding protein (CREB). Phosphorylation of CREB, bound to transcriptional complexes of target genes, activates a down‐stream cascade of transcriptional complexes, which involve in sequence, the nuclear factors TORCs, PGC‐1, NRF1 and NRF2, and the mitochondrial factor mitochondrial transcriptional factor A. CREB also binds directly to the D‐loop of mitochondrial DNA and activates its expression. Activation of this network of transcriptional complexes results in concerted promotion of the expression of nuclear and mitochondrial genes encoding subunits of oxidative phosphorylation complexes. © 2010 IUBMB IUBMB Life, 62(6): 451–456, 2010