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Calnuc: Emerging roles in calcium signaling and human diseases
Author(s) -
Aradhyam Gopala Krishna,
Balivada Lavanya Madhuri,
Kanuru Madhavi,
Vadivel Prabahar,
Vidhya Balasubramanian Shanthi
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.341
Subject(s) - microbiology and biotechnology , biology , calcium signaling , calcium , computational biology , signal transduction , chemistry , organic chemistry
Calnuc is a recently discovered multidomain protein with EF‐hand calcium binding sites. Several studies have reported various interacting partners for calnuc and, therefore, also different sites of localization in the cell. It interacts with important molecules such as DNA, G protein, COX, and amyloid precursor protein among others in addition to being involved in stress response and trafficking. The immense possibilities (of various functions this protein might be involved in) implicate great future in medicine and physiology. Preliminary studies also implicate the possibility of calnuc being involved in some of the human diseases. These initial observations imply the functions that this protein might be involved in. This review emphasizes the importance of further research on this protein. © 2010 IUBMB IUBMB Life, 62(6): 440–450, 2010