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Aboard transthyretin: From transport to cleavage
Author(s) -
Liz Márcia A.,
Mar Fernando M.,
Franquinho Filipa,
Sousa Mónica M.
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.340
Subject(s) - transthyretin , amyloidosis , amyloid (mycology) , chemistry , retinol binding protein , polyneuropathy , transporter , biology , biochemistry , endocrinology , medicine , gene , retinol , inorganic chemistry , vitamin
Abstract Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the transporter of thyroxine (T 4 ) and retinol. Mutated TTR leads to familial amyloid polyneuropathy, a neurodegenerative disorder characterized by TTR amyloid deposition particularly in peripheral nerves. Beside its transport activities, TTR is a cryptic protease and participates in the biology of the nervous system. Several studies have been directed at finding new ligands of TTR to further explore the biology of the protein. From the identified ligands, some were in fact TTR protease substrates. In this review, we will discuss the existent information concerning TTR ligands/substrates. © 2010 IUBMB IUBMB Life, 62(6): 433–439, 2010