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Enzymology of the carnitine biosynthesis pathway
Author(s) -
Strijbis Karin,
Vaz Frédéric M.,
Distel Ben
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.323
Subject(s) - carnitine , biosynthesis , biochemistry , intracellular , metabolite , chemistry , extracellular , membrane , zwitterion , metabolism , metabolic pathway , biology , enzyme , organic chemistry , molecule
Abstract The water‐soluble zwitterion carnitine is an essential metabolite in eukaryotes required for fatty acid oxidation as it functions as a carrier during transfer of activated acyl and acetyl groups across intracellular membranes. Most eukaryotes are able to synthesize carnitine endogenously, besides their capacity to take up carnitine from the diet or extracellular medium through plasma membrane transporters. This review discusses the current knowledge on carnitine homeostasis with special emphasis on the enzymology of the four steps of the carnitine biosynthesis pathway. © 2010 IUBMB IUBMB Life, 62(5): 357–362, 2010