Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease | Zendy

Chang TaYuan | Zendy; Chang Catherine C. Y. | Zendy; Bryleva Elena | Zendy; Rogers Maximillian A. | Zendy; Murphy Stephanie R. | Zendy

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Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease

Author(s) -

Chang TaYuan,

Chang Catherine C. Y.,

Bryleva Elena,

Rogers Maximillian A.,

Murphy Stephanie R.

Publication year - 2010

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1002/iub.305

Subject(s) - cholesterol , disease , alzheimer's disease , amyloid (mycology) , drug , neuroscience , chemistry , cholesterol synthesis , biochemistry , biology , medicine , pharmacology , enzyme , inorganic chemistry , reductase

Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)‐hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD. © 2010 IUBMB IUBMB Life, 62(4): 261–267, 2010

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