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Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease
Author(s) -
Chang TaYuan,
Chang Catherine C. Y.,
Bryleva Elena,
Rogers Maximillian A.,
Murphy Stephanie R.
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.305
Subject(s) - cholesterol , disease , alzheimer's disease , amyloid (mycology) , drug , neuroscience , chemistry , cholesterol synthesis , biochemistry , biology , medicine , pharmacology , enzyme , inorganic chemistry , reductase
Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)‐hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD. © 2010 IUBMB IUBMB Life, 62(4): 261–267, 2010