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Emerging roles of deubiquitinases in cancer‐associated pathways
Author(s) -
Sacco Joseph J.,
Coulson Judy M.,
Clague Michael J.,
Urbé Sylvie
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.300
Subject(s) - ubiquitin , cancer , signalling pathways , deubiquitinating enzyme , biology , signal transduction , microbiology and biotechnology , cancer research , biochemistry , gene , genetics
Abstract Deubiquitinases (DUBs) are emerging as important regulators of many pathways germane to cancer. They may regulate the stability of key oncogenes, exemplified by USP28 stabilisation of c‐Myc. Alternatively they can negatively regulate ubiquitin‐dependent signalling cascades such as the NF‐κB activation pathway. We review the current literature that associates DUBs with cancer and discuss their suitability as drug targets of the future. © 2010 IUBMB IUBMB Life, 62(2): 140–157, 2010