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Is iPS cell the panacea?
Author(s) -
Ou Li,
Wang Xiaochen,
Zou Fangdong
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.289
Subject(s) - sox2 , induced pluripotent stem cell , klf4 , biology , somatic cell , microbiology and biotechnology , stem cell , transplantation , transgene , transcription factor , computational biology , genetics , embryonic stem cell , gene , medicine , surgery
In 2006, it was reported that transgenic expression of merely four defined transcription factors (c‐Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent stem (iPS) cells ignited intense interest in the field of life science for their promising applications in basic biology, drug development, and transplantation. However, the underlying problems of iPS cells seem to be ignored. This review shed light on the problems pertaining iPS cells, including the elusive origin, risk of tumorgenesis, and its relationship with natural selection. © 2010 IUBMB IUBMB Life, 62(3): 170–175, 2010