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The T‐box transcription factor Tbx2: Its role in development and possible implication in cancer
Author(s) -
Abrahams Amaal,
Parker M. Iqbal,
Prince Sharon
Publication year - 2010
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.275
Subject(s) - transcription factor , biology , morphogenesis , embryonic stem cell , cancer , cancer research , microbiology and biotechnology , genetics , gene
Tbx2 is a member of the T‐box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T‐box factors may also play a role in controlling cell cycle progression and in the genesis of cancer. Tbx2 has been implicated in several developmental processes such as coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs including limbs, kidneys, lungs, mammary glands, heart, and craniofacial structures. Importantly, Tbx2 is overexpressed in several cancers including melanoma, small cell lung carcinoma, breast, pancreatic, liver, and bladder cancers and can suppress senescence, a cellular process, which serves as a barrier to cancer development. This review presents a state of the art overview of the role and regulation of Tbx2 in early embryonic development and in cancer. © 2009 IUBMB IUBMB Life, 62(2): 92–102, 2010