Cholesterol‐dependent cytolysins: The outstanding questions | Zendy

Johnstone Bronte A. | Zendy; Joseph Riya | Zendy; Christie Michelle P. | Zendy; Morton Craig J. | Zendy; McGuiness Conall | Zendy; Walsh James C. | Zendy; Böcking Till | Zendy; Tweten Rodney K. | Zendy; Parker Michael W. | Zendy

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Cholesterol‐dependent cytolysins: The outstanding questions

Author(s) -

Johnstone Bronte A.,

Joseph Riya,

Christie Michelle P.,

Morton Craig J.,

McGuiness Conall,

Walsh James C.,

Böcking Till,

Tweten Rodney K.,

Parker Michael W.

Publication year - 2022

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1002/iub.2661

Subject(s) - monomer , microbial toxins , microbiology and biotechnology , virulence , toxin , pore forming toxin , cholesterol , chemistry , virulence factor , biochemistry , biology , gene , polymer , organic chemistry

The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol‐rich membranes, where they oligomerize into ring‐shaped pores of more than 30 monomers. Understanding the details of the steps the toxin undergoes in converting from monomer to a membrane‐spanning pore is a continuing challenge. In this review we summarize what we know about CDCs and highlight the remaining outstanding questions that require answers to obtain a complete picture of how these toxins kill cells.

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