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Placenta‐specific protein 1 promotes cell proliferation via the AKT / GSK ‐3β/cyclin D1 signaling pathway in gastric cancer
Author(s) -
Liu Dongyang,
Shi Ke,
Fu Mingshi,
Chen Feng
Publication year - 2021
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2514
Subject(s) - cyclin d1 , cancer , carcinogenesis , cancer research , mechanism (biology) , biology , gene , cancer cell , cell growth , signal transduction , cell cycle , genetics , philosophy , epistemology
Abstract Gastric cancer is a malignant tumor with a poor prognosis. Therefore, it is important to search for molecules that play a vital role in the development, diagnosis, and treatment of this disease. Placenta‐specific 1 (PLAC1) is one of the cancer‐testis antigens; it plays an important role in both placental development and tumorigenesis. However, the role of PLAC1 in gastric cancer has not been fully investigated, and its underlying mechanism needs further study. We first explored the expression and clinical relevance of PLAC1 in gastric cancer and performed gene set enrichment analysis of PLAC1‐related genes using online databases. Subsequently, we studied the function and mechanism of PLAC1 in gastric cancer cells through in vitro experiments. Our results showed that PLAC1 is highly expressed in gastric cancer, is associated with poor prognosis, and can promote gastric cancer cell proliferation through the AKT/GSK‐3β/cyclin D1 signaling pathway. Moreover, we discovered that AKTi attenuates the effect of PLAC1. Our study further revealed the role and mechanism of PLAC1 in gastric cancer and suggested that this antigen might be a useful molecular marker for gastric cancer diagnosis, prognosis, and treatment.